VDR is a gene which encodes for a protein which acts as a receptor vitamin D which regulates bone growth and calcium absorption. A variant of the gene (rs2228570, FokI polymorphism) is associated with decreased bone mineral density among white prepubescent girls.
The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is regulated by the temporal and reciprocal pattern of on- and off occupancy of the VDRE by two components, and is influenced by chromosomal positions and binding preferences for specific hormones. Microarray studies in human cells show that over 100 genes contain a VDRE. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.
A virtual data room (VDR) is an online storage facility for data and documents pertinent to legal, business, or other activities that have limitations on viewing, downloading or printing. It makes use of a central computer and an extranet that is a restricted-access Internet connection, allowing users to log on at set times.
VDRs are typically used by investment banks and companies involved in mergers and acquisitions. They need a secure platform to share information https://www.gescheftmarketing.de/2021/12/29/gaining-knowledge-and-business-direction/ with investors or potential buyers in a manner that is transparent and due diligence can require huge quantities of data. Life science companies also use VDRs to keep everything from clinical trial results to HIPAA documentation.